RIP1 inhibitor 547

Name	GSK547
Synonyms	RIP1I GSK547 CPD3508 RIP1 inhibitor 547 RIP1 inhibitor GSK547 (S)-6-(4-(5-(3,5-Difluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbonyl)piperidin-1-yl)pyrimidine-4-carbonitrile 4-Pyrimidinecarbonitrile, 6-[4-[[(5S)-5-(3,5-difluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]carbonyl]-1-piperidinyl]-
CAS	2226735-55-1

Molecular Formula	C20H18F2N6O
Molar Mass	396.39
Density	1.43±0.1 g/cm3(Predicted)
Boling Point	578.3±60.0 °C(Predicted)
Solubility	DMSO : 100 mg/mL (252.28 mM; Need ultrasonic)
pKa	1.93±0.28(Predicted)
Storage Condition	-20°C
In vitro study	In Vitro, GSK'547 treatment directed bone marrow-derived macrophages to develop an immunogenic phenotype with upregulated expression of MHC-II, TNFa, and IFNg, while decreasing expression of CD206, IL-10, and TGFb. In addition, GSK'547 also upregulated STAT1 signaling and decreased STAT3, STAT5, and STAT6 signaling in bone marrow-derived macrophages. Macrophages treated with GSK'547 had a stronger ability to capture antigens.
In vivo study	Mice were dosed with GSK'547 via food, and the concentration of GSK'547 in vivo was at a stable level for 24 hours, higher than the IC50 value in L929 cells. High levels of GSK'547 were maintained in vivo during administration for 6 weeks. GSK'547 was well tolerated with no apparent pathological features. In mice with pancreatic ductal adenocarcinoma in situ, GSK'547 reduced their tumor burden and prolonged survival compared to control and Nec-1s treated groups. GSK'547 protects against established tumors and liver metastases.

Last Update：2024-01-02 23:10:35

biological activity	GSK'547 is a highly selective and potent RIP1 (RIPK1) inhibitor, in a mouse pharmacokinetic study, the oral exposure was increased 400-fold compared to GSK' 963.
Target	Value

Last Update：2024-04-09 21:54:55

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Product Name: GSK547 Visit Supplier Webpage Request for quotation
CAS: 2226735-55-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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RIP1 inhibitor 547

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